Contribution a l’étude de l’impact du sécrétome d’Escherichia coli sur le cancer colorectal

Abstract

Colorectal cancer is a multifactorial disease dependent on environmental and genetic factors which constitutes a real problem in public health. The intestinal microbiota is potentially involved in the development of colorectal carcinoma by different mechanisms. We have shown through this research the existence of a link between the bacterial secretome and colorectal cancer, proven by studies which have shown that among these bacteria of the microbiota Escherichia coli has the capacity to synthesize a genotoxin called colibactin which can damage DNA and is a major factor in the development of colorectal cancers.

Keywords : Colorectal cancer, secretome, Escherichia coli, intestinal microbiota, colibactin, DNA