Profil épidémiologique et statut rédox des femmes atteintes du fibrome uterin de la région de Remchi

Abstract

Uterine fibroids, also known as leiomyomas, are the most common tumors of the female reproductive system in women of reproductive age. They are often associated with reproductive disorders, metabolic complications and an increased state of oxidative stress. To better understand the relationship between oxidative stress and uterine fibroids, we conducted a study involving women diagnosed with uterine fibroids, compared to a control group. Various redox status markers (MDA, SOD, and GSH) were analyzed. Furthermore, this study aimed to establish an epidemiological profile of this condition in order to identify the risk factors associated with its development. Significant alterations in redox status were observed in women with uterine fibroids, characterized by elevated levels of malondialdéhyde (MDA) and a decrease in superoxide dismutase (SOD) and reduced glutathione (GSH) levels. Epidemiological data also indicated that women aged between 31 and 40 years are the most affected by this pathology. The majority of the patients with uterine fibroids was married, primiparous, and had a body mass index (BMI) greater than 30. These findings pave the way for new preventive and therapeutic approaches, particularly those involving antioxidant compounds, in the prevention and management of this disease.