Statut Redox et Profil Alimentaire chez une Population de Femmes Atteintes de Cancer du Sein. Etude cas-Témoins

Abstract

Abstract Breast cancer is the most common cancer in women, considered as a multifactorial disease. It involves the main genetic, environmental and nutritional determinants. The objectives of this work are to investigate socio-economic variables and a food survey to look for risk factors in 06 cancer women compared to 15 control women, and to determine certain pro-oxidant markers for the purpose To reveal the existence of a relationship between breast cancer, oxidative stress and nutrition. Our study reports an association between oral contraceptives, family history and the risk of breast cancer, while breastfeeding and physical activity protect against this condition. Exploration of the oxidative stress markers revealed a break in the equilibrium of the oxidizing / antioxidant balance. In fact, these cancerous women represent a highly significant increase in nitric oxide and a high level of superoxide marked by lowered levels of catalase as well as a decrease in levels of cholesterol, LDL-C, uric acid and creatinine compared to the controls. This leads us to conclude that women with breast cancer have metabolic alterations and intra- and extracellular oxidative stress that can compromise their health. Key words: Breast cancer, food consumption, metabolic disturbance, oxidative stress, po-oxidants