Evaluation de la formation du biofilm des souches de Klebsiella pneumoniae isolées de dispositifs médicaux au CHU Tlemcen

Abstract

Over the past few decades, K. pneumoniae has emerged as a significant cause of severe nosocomial infections due to it being difficult to treat. The persistence of this species in hospitals is partly due to its ability to adhere and multiply on inanimate surfaces. Little is known about the bacterial factors involved in K. pneumoniae adhe- rence to abiotic surfaces (Podschun and Ullmann, 1998). It has been previously reported that quorum sensing is involved in biofilm formation by K. pneumoniae (Balestrino et al., 2005). Other studies demonstrated the influence of capsule and extended-spectrum beta-lacta- mase encoding plasmids upon K. pneumoniae adhesion (Hennequin and Forestier, 2007). A high prevalence of type 1 and type 3 pili has been previously observed in clinical and environmental K. pneumoniae isolates (Livrelli et al., 1996; Martynenko et al., 1992; Podschun et al.