E v aluation de l’activité antimicrobienne des microorganismes marins isolés à partir de l’éponge Axinella verrucosa de la région de Honaine (Tlemcen)

Abstract

Algeria harbors a remarkable biodiversity of marine sponges of the genus Axinella verrucosa, particularly the red and yellow species, which host a wide range of symbiotic microorganisms. These microorganisms, especially actinomycetes and actinomycetes and molds, represent a promising source of antimicrobial compounds in response to the growing threat of multidrug resistant pathogens. In this context, we conducted a study during which we collected and analyzed sponge samples, leading to the isolation of 12 f ungal strains, mainly from the Penicillium genus, and four actinomycete strains. Among these, two fungal strains and three actinomycete strains exhibited remarkable antimicrobial activity, notably against Bacillus subtilis and Candida albicans . These findi ngs highlight the biopharmaceutical potential of marine microorganisms associated with Axinella verrucosa as a natural source of new antimicrobial molecules.