Antihyperglycemic Effect of Zygophyllum Geslini Aqueous Extract in Streptozotocin-Induced Diabetic Wistar Rats

Abstract

Diabetes mellitus is a major public health concern. Finding a cure for the disease without its side-effects is the objective of modern medicine. The plant is a raw material for these studies. Zygophyllum geslini is a species widely used in Algeria to treat this disease. Our aim is to investigate the antidiabetic activity of aqueous extract and its fractions in induced diabetic Wistar rats by streptozotocin. The three drugs caused a decrease in blood sugar for 14 days. Butanolic fractions (BF) fraction gives significant results on blood glucose after seven days and significant regulating oral glucose tolerance. This preliminary study shows that Z. geslini is endowed with a remarkable antidiabetic activity and that further studies are needed.