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Titre: Antifungal activity of the Algerian Lawsonia inermis(henna)
Auteur(s): Rahmoun, Nadjib
Boucherit-Otmani, Zahia
Boucherit, Kebir
Benabdallah, Mohammed
Choukchou-Braham, Noureddine
Mots-clés: Antimicrobial agents
natural product
lawsone
bioactive compound Address for Correspondence: Nadjib Rahmoun, Antibiotics Antifungal Laboratory: Physical-Chemistry, Synthesis and Biological Activity, Department of Biology, Faculty of Sciences, BP119, Tlemcen University, Tlemcen 13000, Algeria. Tel: 00213–550440040. E-mail: nagrah113@hotmail.com (Received 26 August 2011; revised 19 May 2012; accepted 06 July 2012) Pharmaceutical Biology, 2013; 51(1): 131–135 © 2013 Informa Healthcare USA, Inc. ISSN 1388-0209 print/ISSN 1744-5116 online DOI: 10.3109/13880209.2012.715166 Pharmaceutical Biology Downlo
Date de publication: 2013
Résumé: Context: Lawsonia inermisLinn. (Lythraceae) or henna has been used since the earliest times as a medicine, preservative, and cosmetic. It has long been recommended in traditional medicine as an astringent, purgative, and abortifacient. Objective: Lawsone and six extracts of L. inermisplant, used by Algerian traditional healers to treat infectious diseases, were screened for their antifungal activity against filamentous fungi. Materials and methods: Water and five organic extracts – DMSO, ethanol, chloroform, ethyl acetate, and di-ethyl ether – of L. inermisleaves, collected in the area of Adrar (Algeria), were prepared by soaking 25 g of powdered plant in 100 mL of solvent. The extracts were screened for antifungal activity using the poisoned food technique against five filamentous fungi. Results: Results demonstrated that the best yield (8.03%) was obtained with the ethanol extract. The commercial lawsone showed potentially interesting MICs against the strains Fusarium oxysporum(12 µg/mL) and Aspergillus flavus(50 µg/mL). The ethanol extract showed the only interesting MIC (230 µg/mL of crude extract) against the strain F. oxysporumcompared with other extracts. Discussion and conclusion: These results suggest that the Algerian L. inermisplant has antifungal activity that can be related to the presence of lawsone in the leaves plant. The results can be exploited largely in research of new antifungal drugs.
URI/URL: http://dspace.univ-tlemcen.dz/handle/112/5624
ISSN: 1388-0209
Collection(s) :Articles internationaux

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