Recherche de nouvelles substances présentes dans quelques espèces de la famille des Astéracées.

Abstract

Algeria abounds in an important floristic biodiversity which constitutes a potential source of natural substances. Therefore, the preservation and development of this invaluable wealth can have considerable economic benefits for the development of the country. Therefore, this research focused on two plants of the genus Carlina and Inula of the Asteraceae family, and more precisely a chemical characterization of their volatile fractions using different analytical techniques (GC, GC-MS, NMR), and a study of biological properties. The analysis of the essential oil of the roots of Carlina hispanica revealed the predominance of an acetylenic compound, and on the other hand the dominant occurrence of oxygenated sesquiterpenes for the essential oil of the aerial parts of Inula montana. However, the biological aspects showed that carlina oxide as well as the essential oil of C. hispanica are endowed with promising anti-inflammatory and antioxidant activity, and the combination of carlina oxide with the references showed a synergistic effect. The essential oil of Inula montana also showed an interesting antioxidant effect. Furthermore, the results of the antimicrobial activity were moderate. An initial work on the inhibition of the receptors of the enzyme superoxide dismutase by the compounds of the essential oil of Inula montana via two methods of computational chemistry was elaborated and revealed that both compounds E-E farnesyl acetate and E- nerolidol acetate are better inhibitors and can be proposed as new drugs with antioxidant potential.