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Titre: Effect of saponosides crude extract isolated from Citrullus Colocynthis (L.) seeds on blood glucose level in normal and streptozotocin induced diabetic rats
Auteur(s): BENMEHDI, Houcine
AZZI, Rachid
LAHFA, Farid
TABTI, Boufeldja
Mots-clés: Citrullus colocynthis L.
Date de publication: 23-déc-2011
Résumé: The effect of saponosides crude extract isolated from the seeds of Citrullus Colocynthis L. Schrad (Cucurbitaceae) on blood glucose level were investigated in normal and diabetic rats (streptozotocin induced). A single and non toxic dose (20 mg/kg bw) of saponosides crude extract were administrated to animals by intraperitoneal route. Lethal doses of saponosides crude extract in healthy rats (DL50 and DL100) were found to be 200 and 250 mg/kg bw, respectively. The results obtained from this study showed no change of glycaemia in normal rats. Whereas, in STZ-treated diabetic animals, the blood glucose level decrease significantly (p<0.05) to reach its normal value 48 h after administration of saponosides crude extract. This antihyperglycaemic effect was maintained during twenty six days after a unique intraperitoneal injection. This effect can be reproduced after return to the diabetic state. Saponosides instigate an antihyperglycaemic and sustainable action in STZ-diabetic rats.
Description: Journal of Medicinal Plants Research, ISSN : 1996-0875, DOI : 10.5897/JMPR11.1369, Issue : 31, Volume : 5, pp. 6864–6868, 23 DEC 2011.
ISSN: 1996-0875
Collection(s) :Articles internationaux

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