Modification de β-cyclodextrine, complexation de Thymol

Abstract

In this master's work, was carried out with high yields a strategy for chemical modification of βcyclodextrin in order to obtain the β-CD derivatives carrying iodine functions, thioethyl amino groups or alkyl chains. Their characterization was done by FTIR spectroscopy. The study of the complexation of β-CD and the β-CDSNH derivative with Thymol (an antibacterial agent) was performed using UV-Visible spectrophotometry. The formation of a complex of type 1 :1 was established for the two complexes β-CDSNH/TM and βCD/TM with a constant of association K = 343 M-1 calculated for this one. The β-CD/TM solid complex was obtained by co-precipitation with a yield of 80 % and a TM encapsulation rate of 63 %. The formation of the βCDSNH/TM complex in solution proves more stable compared to the β-CD/TM complex, which requires more investigation and opens perspectives in this field