Synthèse des glycoconjugués d’intérêt thérapeutique

Abstract

The subject of this thesis is the synthesis of carbohydrate derivatives of fragments of three molecules of therapeutic interest are the hymenistatine, Sansalvamide, and dehydrodidemnine, with the objective of developing some carbohydrate precursors that can be used in the target molecule, and the presence of a sugar moiety in a target could contribute to the additional molecular recognition properties of these products. Three α-amino acids were used in this synthesis, with two couplings for generating two targets Dipeptide couplings between amino acids were carried out with dicyclohexylcarbodiimide generates a urea insoluble in water, and then the synthesis of glucuronic anhydride and the coupling of the latter with the two dipeptides gives the target carbohydrate moieties.