Bousalaa Nassima, SouhilaMedjahdaoui, Faiza2021-10-202021-10-202020https://dspace.univ-tlemcen.dz/handle/112/17515Colorectal cancer is a multifactorial disease dependent on environmental and genetic factors which constitutes a real problem in public health. The intestinal microbiota is potentially involved in the development of colorectal carcinoma by different mechanisms. We have shown through this research the existence of a link between the bacterial secretome and colorectal cancer, proven by studies which have shown that among these bacteria of the microbiota Escherichia coli has the capacity to synthesize a genotoxin called colibactin which can damage DNA and is a major factor in the development of colorectal cancers. Keywords : Colorectal cancer, secretome, Escherichia coli, intestinal microbiota, colibactin, DNAfrColorectal cancer, secretome, Escherichia coli, intestinal microbiota, colibactin, DNAThesis