merad mBoukli, FSoufi, WGhalem, S2013-02-182013-02-182012https://dspace.univ-tlemcen.dz/handle/112/1448alzheimer's disease (ad) is a progressive degenerative disease of the brain marked by gradual and irreversible declines in cognitive functions.acetyl cholinesterase plays a biological role in the termination of nerve impulse.