Benmehdi, HoucineAzzi, RachidDjaziri, RabahLahfa, FaridBenariba, NabilaTabti, Boufeldja2013-04-162013-04-162011-12-231996-0875https://dspace.univ-tlemcen.dz/handle/112/1773Journal of Medicinal Plants Research, ISSN : 1996-0875, DOI : 10.5897/JMPR11.1369, Issue : 31, Volume : 5, pp. 6864–6868, 23 DEC 2011.The effect of saponosides crude extract isolated from the seeds of Citrullus Colocynthis L. Schrad (Cucurbitaceae) on blood glucose level were investigated in normal and diabetic rats (streptozotocin induced). A single and non toxic dose (20 mg/kg bw) of saponosides crude extract were administrated to animals by intraperitoneal route. Lethal doses of saponosides crude extract in healthy rats (DL50 and DL100) were found to be 200 and 250 mg/kg bw, respectively. The results obtained from this study showed no change of glycaemia in normal rats. Whereas, in STZ-treated diabetic animals, the blood glucose level decrease significantly (p<0.05) to reach its normal value 48 h after administration of saponosides crude extract. This antihyperglycaemic effect was maintained during twenty six days after a unique intraperitoneal injection. This effect can be reproduced after return to the diabetic state. Saponosides instigate an antihyperglycaemic and sustainable action in STZ-diabetic rats.enCitrullus colocynthis L.antidiabeticsaponosidesstreptozotocinratsArticle